Collaboration for Rheumatology between HUG and HCY in Cameroun

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HUG project leader Cem Gabay, , Department, division Spécialités de Médecine, Rhumatologie / / e-mail cem.gabay@hcuge.ch, , Country partner Cameroun Project partner abroad Madeleine Ngandeu, , Department, division Médecine Interne, Rhumatologie / / Institution Hôpital Central&Faculté de Médecine, Yaoundé, Cameroun / / e-mail ngandeu@yahoo.com, , Starting date 01/04/2008 Ending date The collaboration project started with the training of Dr Ngandeu as rheumatologist in Geneva in 2000. Professor Gabay then pursued the collaboration by regular visits in Yaoundé with the aim of teaching medical students and post-gardate trainees, as well as providing his expertise for the management of difficult cases (outpatient clinic and rounds). The two institutes also collaborated on a clinical research project on rheumatoid arthritis in Cameroun that included genetic and serological analysis. This research has been successful with several published papers. Dr Ngandeu was recently appointed as Professor and is acting as Vice-Dean at the Medical Faculty of Yaoundé. The collaboration is ongoing with visits of Prof. Gabay in Yaoundé, the training of another rheumatologist, and the extension of the research project to a larger cohort of patients followed in Doualla.  ...

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Cervical cancer screening in Cameroon: Feasibility of a single-visit approach using rapid HPV-testing

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HUG project leader Patrick Petignat, Rosa Catarino, Department, division Département de Gynécologie et Obstétrique / Département de Gynécologie et Obstétrique / e-mail patrick.petignat@hcuge.ch, RosaIsabel.PintoCatarino@hcuge.ch, Country partner Cameroun Project partner abroad Kenfack Bruno, Pierre-Marie Tebeu, Adamo Bongoe Department, division Unité de Santé Reproductive / Département d'obstétrique et gynécologie / Département d'obstétrique et gynécologiec Institution Hopital de District Dschang / Hôpital du Centre Hospitalier Universitaire de Yaoundé / Hopital Regional Edea e-mail brunokenfack@gmail.com, pmtebeu@yahoo.fr, bongoecam@yahoo.com Starting date 01/07/2015 Ending date Cervical cancer is a significant reproductive health problem and the leading cause of cancer death among women in sub-Saharan Africa. Human papillomavirus (HPV) rapid test offers the opportunity to prevent cervical cancer in a single visit. Our goal is to to assess the feasibility and safety to prevent cervical cancer using rapid HPV test. Study site will be a geographically well-defined area in West Region Cameroon (Dschang) with an estimated population of 250,000 inhabitants. Eligible women, aged between 30 and 49, will be invited to perform a rapid HPV self-test (Xpert HPV). HPV-negative women will be reassured and counseled to repeat the test in 5 to 10 years. HPV-positive women will be invited for visual inspection with acetic acid and Lugol (VIA/VILI) and therapy if abnormal. Quality control will be assessed using (i) histology of abnormal results, and (ii) a set of digital photographs of the cervix. Sensitivity, specificity, positive predictive value and negative predictive value will be calculated for the VIA/VILI using histopathology as gold standard. The pictures of the cervix will be analyzed by specialists in Geneva, as part of a telemedicine project. The availability of a rapid HPV self-test provides an unprecedented opportunity to develop a cervical cancer screening programme in a population with low or medium resources in a single-visit approach. The study will also determine the level of support which is needed to implement and maintain high-quality HPV-based cervical cancer detection.  ...

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Feasibility and cost of pegylated liposomal doxorubicin for the treatment of AIDS-associated Kaposi’s sarcoma in Maputo, Mozambique

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HUG project leader Laurence Toutous Trellu, , Department, division Service de dermatologie, HUG / / e-mail laurence.trellu@hcuge.ch, , Country partner Mozambique Project partner abroad Matthew Coldiron, Jean Paul Kimenyi, Lucas Molfino Department, division Epicentre- Médecins sans frontières / Médicos Sem Frontereiras / Médicos sem fronteiras Institution Médecins sans frontières / Médecins sans frontières Suisse / Médecins sans frontières Suisse e-mail mcoldiron@icentre.msf.org, MSFCH-Maputo-epidemio@geneva.msf.org, msfch-maputo-medco@geneva.msf.org Starting date 01/10/2015 Ending date 01/04/2017 Kaposi’s sarcoma (KS) is endemic in many countries of Africa and causes considerable morbidity and mortality in sub-Saharan Africa. The association with HIV infection and loss of immunity worsens the presentation of this tumor known to be associated to Herpes virus 8 (HHV8). Few treatment programs can effectively combat this burden. Some of the reasons for the lack of KS treatment programs are the absence of international guidelines and protocols adapted for resource deprived settings as well as high cost of modern treatment. We propose to introduce a new treatment for Kaposi’s Sarcoma patients at the MSF-CH supported Centro de Referencia do Alto-Maé in Maputo, Mozambique. Specifically, MSF-CH with approval of the Ministry of Health, proposes to substitute the standard therapy of doxorubicin, bleomycin and vincristine (ABV) with pegylated liposomal doxorubicin (PLD), which in clinical trials has been shown to be less toxic and more effective than the standard therapy, but not yet widely used in resource limited settings due to its high costs. Since PLD is not yet used in Mozambique, we here propose to implement it as part of a clinical study with the objective to document its effectiveness and safety in a resource-limited setting.  ...

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Pediatric Epileptology

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HUG project leader CHRISTIAN KORFF, , Department, division DEPARTEMENT DE L'ENFANT ET DE L'ADOLESCENT / / e-mail christian.korff@hcuge.ch, , Country partner Vietnam Project partner abroad Pierre Jallon, , Department, division NEUROPEDIATRIE / / Institution HOPITAL NHI DONG 2 / / e-mail pjallon@gmail.com, , Starting date 10/01/2015 Ending date 17/01/2015 Nhi Dông 2 Hospital(Grall) in Saïgon is one of the biggest pediatric centers in Southeast Asia. Numerous patients with epilepsy are treated there on a daily basis. Expertise in pediatric epileptology remains however insufficient. in Vietnam, despite an estimated prevalence of up to 10% in certain regions of the country (Jallon, RMS, 2006). To our knowledge, no pediatric neurologist with specific education in the field works in Vietnam. An important proportion of epileptic children does not have access to basic care.  ...

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Surgical anatomy of the recurrent laryngeal nerve, a comparative study between an Afrian and a Caucasian population

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HUG project leader Frédéric Triponez, , Department, division Département de Chirurgie, Service de Chirurgie Thoracique et Endocrinienne, HUG / / e-mail frederic.triponez@hcuge.ch, , Country partner Cameroun Project partner abroad Adèle Rose Ngo Nyeki, , Department, division Service d'ORL et chirurgie cervico-faciale / / Institution CHU Yaoundé / / e-mail adelerose_nyeki@yahoo.fr, , Starting date 01/02/2015 Ending date 31/12/2015 Dr Ngo-Nyeki studied the surgical anatomy of the recurrent laryngeal nerve (RLN) in Africa and found some differences in the African population studied (62 patients) as compared to what is described in anatomy books in which the patients were mostly Caucasians. the idea of this study is to compare with the same criteria and by the same person the surgical antomy of the RLN in an African population were she is currently practising and in a Caucasian population in Geneva.  ...

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Clinical training in the pacemaker for Cameroon

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This project consists first to complete the training in general cardiology of Doctor Mondouagne, then training in pacing (implantation, explantation and monitoring pacemakers) in the clinical activity of HUG, supervised by Doctors Burri and Sunthorn. After training, Dr. Mondouagne is guaranteed to integrate Douala General Hospital, a center of reference of the sub-region of Central Africa, which already has an operational infrastructure.

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